Figure 3.

Phage–bacteria dynamics for bacterial density-dependent burst size and realistic latent period distributions. Phage and bacterial numbers (PFU/ml and CFU/ml) were simulated for 500 h starting from an initial MOI = 1 (parameters are given in Table S1). Population dynamics are shown for (A) bacterial density-dependent burst size with resistance evolution; (B and C) gamma-distributed latent periods with (B) one or (C) five infected stages without resistance evolution (see Fig. S3 for (B) and (C) with resistance evolution). For (B) and (C), lower adsorption rate (α =10⁻⁹) and higher phage decay rate (ω =0.33) were used. Orange indicates susceptible cells, dashed green indicates free phages, and dark blue indicates genetically resistant cells. In (B) and (C), yellow shows the first infected stage and gray shows the last one (both overlap with the orange S curve).