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. 2022 Jun 15;22(10):2306–2322. doi: 10.1111/ajt.17116

FIGURE 4.

FIGURE 4

Ischemia reperfusion injury, MCMV infection, and allogeneic transplantation each contribute to intragraft Th17 cell infiltration. (A) Syngeneic transplantation was performed using D−R− and D+R+ grafts to evaluate role of ischemia–reperfusion injury (IRI) without alloimmune responses. (B) CCL20 and CXCL10 quantities in D−R− and D+R+ syngeneic transplants. (C) Frequencies of Th17 infiltrates in syngeneic D−R− and D+R+ grafts. (D) Intragraft Th17 cells co‐expressing IFN‐γ and/or TNF‐α in D−R− and D+R+ grafts. (E) Percentage and proportions of single or multiple cytokines expressing Th17 cells in syngeneic and allogeneic grafts. For (A–D), data are represented as mean ± standard deviation (SD) and are analyzed by two‐sided Student's t‐test. For (E), mean values are shown.