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. 2022 Oct 8;13(10):858. doi: 10.1038/s41419-022-05307-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A In normal bronchial and alveolar epithelia, negative PLEKHH2 staining was detected via immunohistochemical analysis. NSCLC samples showed cytoplasmic accumulation of PLEKHH2 protein, and it occurred more frequently in tumors with poorer differentiation (Rabbit IgG was used as a negative control; Scale bar, 50 μm). B Overexpression of PLEKHH2 correlates with poor patient survival. Among the 170 cases with follow-up information, Kaplan-Meier curves showed that patients with PLEKHH2 overexpression (94 cases) had a shorter survival time than those with normal PLEKHH2 expression (76 cases) (P = 0.014). C Western blot analysis of PLEKHH2 expression in lung cancer cells. Increased PLEKHH2 expression was detected in lung cancer cell lines compared to the immortalized bronchial epithelial cell line HBE. D PLEKHH2 protein levels were normalized to those of GAPDH. Statistical analysis showed increased PLEKHH2 expression in lung cancer cell lines compared to HBE cells. E Laser confocal microscopy images show that cytoplasmic PLEKHH2 expression was higher in lung cancer cells than in HBE cells. (PLEKHH2-CRISPR/CAS9 was used as negative control; Original magnification ×400). P < 0.05 indicates statistical significance, **P < 0.01, ***P < 0.001.