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. Author manuscript; available in PMC: 2023 Oct 5.
Published in final edited form as: Neuron. 2022 Aug 19;110(19):3121–3138.e8. doi: 10.1016/j.neuron.2022.07.020

Figure 8. CA2 silencing reduced nonconvulsive seizure frequency.

Figure 8.

(A, B) A representative example of a nonconvulsive seizure in an Amigo2-Cre mouse expressing hM4D(Gi)-mCherry in CA2. Despite the absence of behavioral indicators (A), EEG revealed significant seizure activity in all electrodes (B). (C) CNO reduced nonconvulsive seizure frequency. (D) CNO did not alter seizure duration (paired t-test; t = 0.6743, df = 6; P = 0.5252; n = 8 mice). (E) CNO did not reduce nonconvulsive seizure frequency in two control groups of mice described in the previous figure (paired t-test; t = 0.1333, df = 11; P = 0.8963; n = 12 mice). (F) CNO did not reduce nonconvulsive seizure duration in control groups (paired t-test; t = 0.2927, df = 5; P = 0.7815; n = 6 mice).