Table 1.
Patient Characteristics and Study Instruments by Age Group
| Young Adult (n=194) | Older Adult (n=785) | ||||
|---|---|---|---|---|---|
| Variable | N | % | N | % | P-Value |
| Patient and Transplant Charecteristics | |||||
| Age at HCT, years (mean + SD, [range]) | 31 ± 6 (19.1–39.8) | 56 ± 8 (40.0–84.5) | - | ||
| Sex (Male) | 89 | 45.90% | 457 | 58.20% | 0.002 |
| Race | 0.28 | ||||
| Asian | 6 | 3.10% | 12 | 1.50% | |
| Black | 7 | 3.60% | 18 | 2.30% | |
| Multiple Races | 3 | 1.50% | 10 | 1.30% | |
| Native American | 3 | 1.50% | 5 | 0.60% | |
| White | 175 | 90.20% | 740 | 94.30% | |
| Ethnicity | 0.2 | ||||
| Hispanic | 12 | 6.20% | 32 | 4.10% | |
| Non-Hispanic | 179 | 92.30% | 743 | 94.60% | |
| Unknown | 3 | 1.50% | 10 | 1.30% | |
| Years from transplant to study entry (mean + SD, [range]) | 5.2 ± 2.2 , (1.2–10.7) | 5.1 ± 2.1 (1.0–10.9) | 0.59 | ||
| Diagnosis | <0.0001 | ||||
| Acute Lymphoblastic Leukemia | 32 | 16.50% | 32 | 4.10% | |
| Acute Myeloid Leukemia | 48 | 24.70% | 167 | 21.30% | |
| Chronic Lymphoblastic Leukemia | 3 | 1.50% | 17 | 2.20% | |
| Chronic Myeloid Leukemia | 7 | 3.60% | 21 | 2.70% | |
| Hodgkin Lymphoma | 43 | 22.20% | 43 | 5.50% | |
| Myelodysplastic Syndrome/ MPN | 17 | 8.80% | 98 | 12.50% | |
| Non-Hodgkin Lymphoma | 42 | 21.60% | 402 | 51.20% | |
| Other leukemia | 2 | 1.00% | 5 | 0.60% | |
| Total Body Irradiation | 69 | 35.60% | 137 | 17.50% | <0.0001 |
| Transplant Type | 0.004 | ||||
| Autologous | 79 | 40.70% | 411 | 52.40% | |
| Allogeneic | 115 | 59.30% | 374 | 47.60% | |
| History of cGVHD (allogeneic only) | 0.21 | ||||
| Yes | 97 | 84.30% | 332 | 80.80% | |
| No | 18 | 15.70% | 42 | 10.20% | |
| Study Instruments (mean +SD) | |||||
| Short Form-12 Physical Component Score | 48.99 | 11.09 | 47.18 | 10.8 | 0.049 |
| Short Form-12 Mental Component Score | 48.4 | 11.49 | 50.23 | 10.47 | 0.04 |
| Cancer and Treatment Distress Overall | 0.96 | 0.69 | 0.85 | 0.61 | 0.04 |
| Cancer and Treatment Distress Subscales | |||||
| Health Burden | 1.22 | 0.96 | 1.27 | 0.88 | 0.55 |
| Uncertainty | 1.08 | 0.74 | 0.95 | 0.72 | 0.03 |
| Family Strain | 0.88 | 0.87 | 0.79 | 0.81 | 0.18 |
| Finances | 0.98 | 0.97 | 0.77 | 0.82 | 0.003 |
| Identity | 0.92 | 0.8 | 0.8 | 0.73 | 0.051 |
| Medical Demands | 0.58 | 0.67 | 0.47 | 0.59 | 0.03 |
| Health Self-Efficacy | 2.93 | 0.47 | 3.08 | 0.5 | 0.0004 |
Note: YA: Young Adult; HCT: Hematopoietic Cell Transplant; SD: standard deviation; MPN: Myeloproliferative Neoplasm; cGVHD: chronic graft versus host disease; Short Form-12 (higher value is better functioning), Cancer and Treatment Distress (lower number indicates less distress)