Fig. 3.

Heatmap of the Spearman’s rank correlation of species and urinary or plasma metabolites. Red squares indicate positive associations between these microbial species and clinical indexes. Blue squares indicate negative associations. The statistical significance was denoted inside the squares (*P < 0.05; **P < 0.01). A 2272 pairs of correlations with 71 bacteria species and 32 urinary metabolites were plotted. B 1197 pairs of correlations with 57 bacteria species and 21 plasma metabolites were plotted