Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 8;20:459. doi: 10.1186/s12967-022-03669-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Gut microbiota taxonomic and functional comparison between CIS and the controls. A depicts the indices of alpha-diversity. B depicts the Principal Coordinates Analysis (PCoA) of beta-diversity. Each point represents a single sample in CIS and the controls. The two principal components (PC1 and PC2) explained 24% and 17%. C shows the relative abundance of KEGG pathways of functional annotations in the gut microbiota. The barplot with 95% confidence intervals denote the significantly different KEGG pathways between CIS and controls. D Gut bacterium-bacterium ecological network in CIS versus the controls. Correlations between taxa were calculated through Spearman’s rank correlation analysis. Statistical significance was determined for all pairwise comparisons. Only statistically significant correlations (P < 0.05) with |r|> 0.5 were plotted. The size of node, corresponding to individual microbial species, is proportional to the number of significant inter-species correlations. The color of node indicates the phylum to which the corresponding microbial species belong to. The color intensity of connective lines is proportional to the correlation coefficient, where blue lines indicate inverse correlations and red lines indicate positive correlations