Fig. 3.

FDA-approved therapeutic drugs for breast cancers. a Distribution of therapeutic drugs for breast cancers during the past 31 years (adapted from [863]). b Microtubule inhibitors. c Antimetabolite. d DNA topoisomerase inhibitor. e Aromatase inhibitors. f ER inhibitors. g CDK4/6 inhibitors. h HER2-directed mAbs. i HER2-directed ADCs. j HER2 inhibitors. k PARP inhibitor. l PI3Kα inhibitor. m Trop-2-directed ADC