Table 5.
Neuropharmacological activity of the extracts by open field test
Group | Dosage | Movement Quantity (percentage of movements inhibition) | ||||
---|---|---|---|---|---|---|
0 min | 30 min | 60 min | 90 min | 120 min | ||
Control | 10 ml/kg | 36.2±5.54 | 37.6±3.85 | 35.8±6.11 | 39.6±4.11 | 40.2±3.28 |
Standard | 1 | 14.8±3.47* | 15.2±4.02* | 18.8±4.55* | 20.2±4.14* | 18.8±4.12* |
EE | 100 | 34.8±2.65 | 28.2±2.85 | 30.4±1.66 | 29.8±2.48* | 27.0±2.76* |
EE | 200 | 24.6±3.44 | 26.8±2.92 | 26.8±2.11 | 23.4±1.66* | 26.6±1.50* |
AE | 100 | 32.0±3.19 | 27.2±2.35 | 28.4±2.11 | 28.6±2.04* | 35.2±4.61 |
AE | 200 | 27.4±2.30 | 28.2±2.76 | 28.4±4.85 | 25.6±1.29* | 28.6±3.19* |
ETAE | 100 | 35.2±3.77 | 30.4±3.17 | 24.2±3.31* | 23.0±2.61* | 28.4±1.83* |
ETAE | 200 | 16.6±2.20* | 28.6±2.52 | 25.4±4.30* | 26.8±1.46* | 27.2±2.20* |
EE: ethanol extract; AE: acetone extract; ETAE: ethyl acetate. Results are presented as Mean± SEM (n=5), *P<0.05, statistically significant in comparison with the control group (two-way ANOVA followed by Bonferroni's test)