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. 2022 Jun 7;10(10):3475–3484. doi: 10.1002/fsn3.2949

TABLE 1.

Factors and levels in response surface methodology (RSM)

Independent variable Symbol Level
−1 0 1
Ethanol concentration (%) X 1 35 62.5 90
Solvent‐to‐material ratio (ml/g) X 2 15 22.5 35
Ultrasonic time (min) X 3 15 35 55
Ultrasonic power (W) X 4 100 300 500