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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Atherosclerosis. 2022 May 14;351:18–25. doi: 10.1016/j.atherosclerosis.2022.05.007

Table 2.

Associations of circulating immune cell subsets with incident stroke (all) and ischemic stroke in MESA (N = 2104).

Stroke (all)
 Ischemic stroke
 
 Model 0
 Model 1 (Primary)
 Model 0
 Model 1 (Primary)
Cell subset HR 95% CI p value HR 95% CI p value HR 95% CI p value HR 95% CI p value
Classical monocytes 0.84 (0.70, 1.01) 0.06 0.83 (0.64, 1.08) 0.16 0.83 (0.68, 1) 0.05 0.76 (0.56,1.04) 0.08
Intermediate monocytes 1.33 (1.14, 1.56) <0.001 1.35 (1.06, 1.71) 0.01 1.31 (1.10, 1.56) 0.003 1.41 (0.99, 2.00) 0.055
Nonclassical monocytes 0.89 (0.72, 1.11) 0.3 0.86 (0.61, 1.21) 0.38 0.95 (0.76, 1.18) 0.63 0.99 (0.71, 1.38) 0.96
Natural killer cells 1.03 (0.87, 1.22) 0.74 0.96 (0.75, 1.23) 0.76 1.03 (0.86, 1.23) 0.75 0.93 (0.71, 1.22) 0.61
Gamma-delta T cells 0.92 (0.71, 1.18) 0.51 0.89 (0.59, 1.35) 0.60 0.95 (0.74, 1.23) 0.69 0.98 (0.66, 1.45) 0.92
Pan CD4+ T cells 1.06 (0.82, 1.36) 0.68 1.14 (0.79, 1.65) 0.49 1.09 (0.82, 1.44) 0.56 1.15 (0.73,1.81) 0.54
Th1 1.02 (0.75, 1.37) 0.93 0.88 (0.64, 1.20) 0.41 1.06 (0.78, 1.45) 0.71 0.95 (0.68, 1.34) 0.77
Th2 1.33 (1.09, 1.61) 0.004 1.48 (1.11, 1.98) 0.007 1.35 (1.09, 1.67) 0.007 1.51 (1.09, 2.08) 0.013
Th17 0.89 (0.67, 1.18) 0.41 0.79 (0.49, 1.27) 0.33 0.95 (0.74, 1.24) 0.72 0.92 (0.62, 1.38) 0.70
Treg (CD4+CD25+ CD127−) 1.09 (0.90, 1.32) 0.41 1.20 (0.90, 1.61) 0.21 1.08 (0.89, 1.32) 0.44 1.17 (0.86, 1.57) 0.32
CD4+CD45RA+ 0.84 (0.68, 1.03) 0.10 0.98 (0.73, 1.31) 0.88 0.82 (0.64, 1.04) 0.097 0.95 (0.68, 1.34) 0.78
CD4+CD45RO+ 1.04 (0.85, 1.27) 0.68 0.97 (0.73, 1.27) 0.80 1.05 (0.83, 1.33) 0.68 1.00 (0.71, 1.41) 0.99
CD4+CD25+ 1.44 (1.17, 1.78) <0.001 1.62 (1.16, 2.26) 0.004 1.52 (1.23, 1.88) <0.001 1.74 (1.23, 2.45) 0.002
CD4+CD28− 0.81 (0.64, 1.01) 0.06 0.72 (0.54, 0.97) 0.03 0.86 (0.68, 1.10) 0.24 0.77 (0.55, 1.07) 0.12
CD4+CD57− 0.91 (0.71, 1.16) 0.42 0.93 (0.69, 1.26) 0.64 0.91 (0.70, 1.18) 0.46 0.88 (0.62, 1.26) 0.49
CD4+CD28−CD57+ 0.73 (0.56, 0.95) 0.02 0.61 (0.43, 0.85) 0.003 0.78 (0.59, 1.04) 0.09 0.64 (0.44, 0.93) 0.02
CD4+CD28−CD57+CD45RA+ 0.79 (0.64, 0.97) 0.03 0.77 (0.59, 0.99) 0.047 0.82 (0.66, 1.02) 0.08 0.78 (0.58, 1.05) 0.1
Pan CD8+ T cells 0.9 (0.72, 1.13) 0.36 0.81 (0.60, 1.08) 0.15 0.92 (0.72, 1.19) 0.54 0.82 (0.57, 1.18) 0.29
Tc1 1.19 (0.92, 1.54) 0.19 1.28 (0.89, 1.83) 0.18 1.30 (0.99, 1.72) 0.06 1.51 (1.02, 2.23) 0.04
Tc2 1.27 (1.01, 1.58) 0.04 1.35 (1.04, 1.76) 0.03 1.32 (1.04, 1.67) 0.02 1.42 (1.07, 1.88) 0.02
Tc17 1.07 (0.89, 1.30) 0.47 1.08 (0.85, 1.36) 0.54 1.1 (0.90, 1.34) 0.35 1.09 (0.84, 1.41) 0.51
CD8+CD45RA+ 0.99 (0.77, 1.27) 0.91 1.18 (0.84, 1.64) 0.34 1.09 (0.84, 1.42) 0.54 1.24 (0.87, 1.77) 0.24
CD8+CD45RO+ 0.94 (0.73, 1.21) 0.61 0.85 (0.62, 1.17) 0.32 0.79 (0.61, 1.04) 0.09 0.77 (0.54, 1.10) 0.15
CD8+CD28− 0.85 (0.67, 1.08) 0.19 0.90 (0.65, 1.23) 0.50 0.89 (0.69, 1.15) 0.36 0.98 (0.69, 1.39) 0.90
CD8+CD57+ 0.87 (0.67, 1.12) 0.28 1.05 (0.76, 1.45) 0.79 0.86 (0.66, 1.12) 0.26 0.99 (0.70, 1.42) 0.99
CD8+CD28−CD57+ 0.85 (0.66, 1.08) 0.18 0.98 (0.70, 1.35) 0.89 0.85 (0.66, 1.10) 0.22 1.003 (0.70, 1.44) 0.99
CD8+CD28−CD57+CD45RA+ 0.91 (0.71, 1.17) 0.46 1.11 (0.81, 1.53) 0.51 0.97 (0.75, 1.26) 0.82 1.17 (0.83, 1.65) 0.37
CD19+ 1.03 (0.85, 1.25) 0.78 1.01 (0.76, 1.35) 0.94 0.94 (0.74, 1.19) 0.60 0.97 (0.65, 1.44) 0.88

HR, Hazard Ratio; CI, Confidence Interval.

Red indicates association of subset with increased risk for stroke (all or ischemic) and blue indicates association with decreased risk for stroke; dense red or blue indicates significance after Bonferroni correction (p < 0.0018) and lighter red or blue indicates borderline significance (p < 0.05 but > 0.0018).

Model 0: Adjusted for age (years), gender, race, MESA site.

Primary Model (Model 1): Adjusted for age (years), sex, race/ethnicity, MESA site, educational attainment, smoking status, alcohol, systolic blood pressure, body-mass index, and diabetes mellitus (DM).