Table 3.
Sex-stratified associations of circulating immune cell subsets with incident stroke in MESA (N = 2104).
| Women |
Men |
Interaction Term p value | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | ||
| Classical monocytes | 1.08 | (0.73,1.61) | 0.70 | 0.72 | (0.49,1.05) | 0.09 | 0.039 |
| Intermediate monocytes | 1.06 | (0.66,1.69) | 0.82 | 1.64 | (1.01,2.67) | 0.045 | 0.134 |
| Nonclassical monocytes | 0.80 | (0.44,1.45) | 0.46 | 0.88 | (0.58,1.33) | 0.54 | 0.562 |
| Natural killer cells | 1.02 | (0.61,1.70) | 0.95 | 0.89 | (0.67,1.18) | 0.42 | 0.931 |
| Gamma-delta T cells | 1.04 | (0.71,1.53) | 0.85 | 0.84 | (0.46,1.54) | 0.57 | 0.651 |
| Pan CD4+ T cells | 1.14 | (0.69,1.87) | 0.62 | 1.18 | (0.67,2.08) | 0.57 | 0.948 |
| Th1 | 0.89 | (0.63,1.26) | 0.52 | 0.87 | (0.46,1.64) | 0.67 | 0.979 |
| Th2 | 1.27 | (0.93,1.73) | 0.13 | 1.79 | (1.23,2.62) | 0.003 | 0.46 |
| Th17 | 0.63 | (0.25,1.59) | 0.33 | 0.94 | (0.61,1.45) | 0.79 | 0.364 |
| Treg (CD4+CD25+ CD127−) | 1.29 | (0.84,1.98) | 0.24 | 1.14 | (0.80,1.64) | 0.47 | 0.654 |
| CD4+CD45RA+ | 1.11 | (0.75,1.64) | 0.60 | 0.82 | (0.52,1.3) | 0.40 | 0.153 |
| CD4+CD45RO+ | 0.81 | (0.56,1.17) | 0.26 | 1.16 | (0.77,1.77) | 0.48 | 0.093 |
| CD4+CD25+ | 1.52 | (0.85,2.71) | 0.16 | 1.83 | (1.20,2.81) | 0.005 | 0.569 |
| CD4+CD28− | 0.89 | (0.62,1.29) | 0.54 | 0.61 | (0.38,0.99) | 0.04 | 0.206 |
| CD4+CD57− | 1.21 | (0.78,1.86) | 0.39 | 0.78 | (0.52,1.18) | 0.24 | 0.148 |
| CD4+CD28−CD57+ | 0.73 | (0.47,1.13) | 0.15 | 0.53 | (0.31,0.91) | 0.02 | 0.355 |
| CD4+CD28−CD57+CD45RA+ | 0.95 | (0.70,1.28) | 0.73 | 0.67 | (0.43,1.03) | 0.07 | 0.193 |
| Pan CD8+ T cells | 0.71 | (0.43,1.18) | 0.19 | 0.87 | (0.58,1.31) | 0.51 | 0.584 |
| Tc1 | 0.87 | (0.57,1.34) | 0.53 | 1.89 | (1.19,3.01) | 0.007 | 0.021 |
| Tc2 | 1.26 | (0.99,1.60) | 0.06 | 1.64 | (1.14,2.35) | 0.007 | 0.203 |
| Tc17 | 1.17 | (0.79,1.72) | 0.44 | 1.05 | (0.76,1.47) | 0.75 | 0.886 |
| CD8+CD45RA+ | 1.07 | (0.62,1.87) | 0.8 | 1.18 | (0.79,1.75) | 0.43 | 0.944 |
| CD8+CD45RO+ | 0.86 | (0.48,1.53) | 0.60 | 0.85 | (0.6,1.22) | 0.38 | 0.606 |
| CD8+CD28− | 0.90 | (0.56,1.42) | 0.64 | 0.84 | (0.54,1.30) | 0.43 | 0.961 |
| CD8+CD57+ | 1.19 | (0.76,1.85) | 0.45 | 0.90 | (0.57,1.43) | 0.67 | 0.44 |
| CD8+CD28−CD57+ | 1.04 | (0.66,1.65) | 0.85 | 0.91 | (0.58,1.42) | 0.67 | 0.752 |
| CD8+CD28−CD57+CD45RA+ | 1.09 | (0.69,1.73) | 0.70 | 1.08 | (0.71,1.62) | 0.73 | 0.899 |
| CD19+ | 1.26 | (0.98,1.60) | 0.07 | 0.73 | (0.36,1.50) | 0.39 | 0.123 |
HR, Hazard Ratio; CI, Confidence Interval.
Red indicates association of subset with increased risk for stroke (all or ischemic) and blue indicates association with decreased risk for stroke; dense red or blue indicates significance after Bonferroni correction (p < 0.0018) and lighter red or blue indicates borderline significance (p < 0.05 but > 0.0018).
Primary Model (Model 1): Adjusted for age (years), sex, race/ethnicity, MESA site, educational attainment, smoking status, alcohol, systolic blood pressure, body-mass index, and diabetes mellitus (DM).