Table 4.
Meta-analysis of leukocyte subsets and incident stroke in MESA (N = 2104) and CHS (N = 1793).
| MESA (N = 2104) |
CHS(N = 1793) |
Meta-Analysis (N = 3897) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| CD19+ | 1.002 | (0.96,1.045) | 0.941 | 1.002 | (0.993,1.011) | 0.627 | 1.002 | (0.993,1.011) | 0.623 |
| Gamma-delta T cells | 0.981 | (0.912,1.054) | 0.597 | 1.007 | (0.979,1.035) | 0.648 | 1.003 | (0.977,1.03) | 0.814 |
| Natural killer cells | 0.993 | (0.953,1.036) | 0.755 | 0.957 | (0.924,0.992) | 0.016 | 0.972 | (0.946,0.999) | 0.041 |
| Pan CD4+ T cells | 1.012 | (0.979,1.046) | 0.488 | 1 | (0.991,1.009) | 0.995 | 1.001 | (0.992,1.01) | 0.849 |
| CD4+CD25+ | 1.043 | (1.013,1.074) | 0.004 | 1.005 | (0.996,1.015) | 0.288 | 1.009 | (1,1.018) | 0.057 |
| CD4+CD25+CD127− | 1.087 | (0.954,1.238) | 0.21 | 0.997 | (0.966,1.029) | 0.864 | 1.002 | (0.972,1.033) | 0.897 |
| CD4+CD28− | 0.968 | (0.939,0.997) | 0.032 | 1.004 | (0.995,1.014) | 0.384 | 1.001 | (0.991,1.01) | 0.874 |
| CD4+CD28−CD57+ | 0.941 | (0.904,0.98) | 0.003 | 1.009 | (0.995,1.023) | 0.213 | 1.002 | (0.989,1.015) | 0.817 |
| CD4+CD28−CD57+CD45RA+ | 0.945 | (0.894,0.999) | 0.047 | 1 | (0.978,1.022) | 0.982 | 0.992 | (0.971,1.013) | 0.444 |
| CD4+CD45RA+ | 0.998 | (0.975,1.021) | 0.877 | 0.997 | (0.986,1.007) | 0.529 | 0.997 | (0.987,1.006) | 0.524 |
| CD4+CD45+RO+ | 0.998 | (0.979,1.017) | 0.802 | 0.996 | (0.988,1.005) | 0.398 | 0.997 | (0.989,1.004) | 0.383 |
| CD4+CD57+ | 0.994 | (0.971,1.018) | 0.641 | 1.009 | (0.999,1.018) | 0.066 | 1.007 | (0.998,1.016) | 0.125 |
| Pan CD8+ T cells | 0.977 | (0.947,1.009) | 0.153 | 1.002 | (0.988,1.015) | 0.819 | 0.998 | (0.985,1.01) | 0.716 |
| CD8+CD28− | 0.993 | (0.973,1.013) | 0.499 | 0.998 | (0.991,1.005) | 0.531 | 0.997 | (0.99,1.004) | 0.414 |
| CD8+CD28−CD57+ | 0.999 | (0.978,1.019) | 0.886 | 0.997 | (0.989,1.005) | 0.416 | 0.997 | (0.99,1.004) | 0.417 |
| CD8+CD28−CD57+CD45RA+ | 1.008 | (0.986,1.03) | 0.506 | 0.997 | (0.988,1.006) | 0.501 | 0.998 | (0.99,1.007) | 0.716 |
| CD8+CD45RA+ | 1.011 | (0.989,1.034) | 0.34 | 1.001 | (0.993,1.009) | 0.766 | 1.002 | (0.995,1.01) | 0.548 |
| CD8+CD45+RO+ | 0.986 | (0.959,1.014) | 0.319 | 0.999 | (0.989,1.008) | 0.794 | 0.997 | (0.989,1.006) | 0.569 |
| CD8+CD57+ | 1.003 | (0.983.1.023) | 0.785 | 1.001 | (0.993,1.008) | 0.877 | 1.001 | 0.994,1.008) | 0.809 |
Model: Adjusted for age (years), sex, race/ethnicity, MESA site, educational attainment, smoking status, alcohol, systolic blood pressure, body-mass index, and diabetes mellitus (DM). Hazard ratios are expressed per unit (1%) increase in exposure.