Table 1. The exemplary rodent models of obesity.

Type of the obesity model	Underlying mechanism
For the extensive description of the animals used in obesity studies, please see the reviews[86,97−98].
Diet-based models	Exceeded calories intake in mice or rats: high-fat diet, high-carbohydrate diet, 'cafeteria' diet
Monogenic obesity models	Spontaneous mutation in the gene coding for leptin (ob/ob mice) or for leptin receptor (db/db mice, Zucker fatty rat)
Polygenic obesity models	Selected, susceptible for obesity, inbred strains of mice (New Zealand obese mouse, Tsumura Suzuki obese diabetes mouse) or rats (Wistar Ottawa Karlsburg W Rat, Otsuka Long-Evans Tokushima Fatty Rat)
Surgical models	Lesions of hypothalamus nuclei (e.g., ventromedial or lateral) in mice or rats