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. 2022 Oct 5;10:tkac033. doi: 10.1093/burnst/tkac033

Figure 2.

Figure 2.

Adhesive patches molecularly bind to tissue. (a) Primary amines covalently bonding with carboxylic acids on tissues with coupling reagents (NHS and EDC). (Reprinted from ref. [48] with permission from the American Association for the Advancement of Science.) (b) Adhesive tapes based on carboxylic acid groups covalently bonded with primary amines on tissues to form intermolecular bonds with tissue surfaces (Reprinted from ref. [49] with permission from Springer Nature Limited.) (c) Photo-triggered hydrogel: the UV photo-generated aldehydes on HA-NB react with amines on G-MA; simultaneously, the generated aldehydes interact with amines on tissue. (Reprinted from ref. [56] with permission from Springer Nature Limited.) (d) (i) Pre-crosslinked G-MA hydrogel network strengthened by TA; (ii) G-MA-TA adhesion gel adhering to porcine skins by H-bonding; (iii) hydrogel adhesive healed gastric incision without suture. (Reprinted from ref. [61] with permission from Elsevier B.V.) (e) Pressure-sensitive egg white albumen adhesion on multi-substrates by intramolecular–intermolecular hydrogen bonding of peptide chains (Reprinted from ref. [66] with permission from John Wiley & Sons, Inc.) NHS N-hydroxysuccinimide, EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, UV ultraviolet, TA tannic acid