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. 2022 Oct 10;6:71. doi: 10.1038/s41698-022-00314-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Gene set enrichment analysis of differentially expressed genes (absolute fold change >1.8 and adjusted P value <0.05) in Epithelial 2 cluster in laryngeal SCC vs two regressing lesions. b Dot plot of increased expression of APOBEC3A, ATF3, IFI6, IFI27, ISG15, and IRF1 in Epithelial 2 cluster in laryngeal SCC (PD) vs two regressing lesions (PR). c DDOST^558C>U RNA editing is exclusively observed in laryngeal SCC, mainly in tumor cells. Epi: epithelial cell; non-Epi: non-epithelial cells.