TABLE 2.

The details of the common DEGs.

No.	Gene symbol	Full name	Function
1	IL1B	Interleukin 1 beta	This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
2	HMOX1	Heme oxygenase 1	Heme oxygenase, an essential enzyme in heme catabolism.
3	FADS1	Fatty acid desaturase 1	The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain.
4	CDKN2A	Cyclin dependent kinase inhibitor 2A	This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
5	MAP3K11	Mitogen-activated protein kinase kinase kinase 11	This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
6	DNAJB6	DnaJ heat shock protein family (Hsp40) member B6	This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the “J-domain” and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly.
7	NDRG1	N-myc downstream regulated 1	The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis.
8	SLC1A5	Solute carrier family 1 member 5	The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus
9	PTEN	Phosphatase and tensin homolog	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
10	TIMP1	TIMP metallopeptidase inhibitor 1	This gene belongs to the TIMP gene family. The encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
11	HIF1A	Hypoxia inducible factor 1 subunit alpha	This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
12	PRKCA	Protein kinase C alpha	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control.
13	ATF3	Activating transcription factor 3	This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response.
14	SLC39A14	Solute carrier family 39 member 14	This gene encodes a member of the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis.