TABLE 3.

Mendelian randomization estimates of hypertension on the risk for HF and IS.

Trait	Method	SNPs (n)	OR	95% CI	P-value	P-value for Cochran’s Q	P-value for Mr-egger intercept	F- statistic (total)
Heart failure							0.10	18
	MR Egger	47	1.04	0.87–1.25	0.64	6.50E-06
	Weighted median	47	1.18	1.12–1.25	8.50E-09
	IVW	47	1.21	1.15–1.28	7.37E-12	1.61E-06
	Maximum likelihood	47	1.22	1.18–1.27	2.30E-25
	IVW (fixed)	47	1.21	1.17–1.26	4.01E-25
	MR-PRESSO*	47	1.21	1.15–1.27	1.59E-09
Ischemic stroke							0.12	17
	MR Egger	53	1.12	0.91–1.38	0.28	1.31E-04
	Weighted median	53	1.24	1.15–1.34	6.36E-08
	IVW	53	1.32	1.24–1.41	5.80E-19	5.33E-05
	Maximum likelihood	53	1.34	1.28–1.40	8.50E-35
	IVW (fixed)	53	1.32	1.26–1.38	2.42E-35
	MR-PRESSO*	53	1.35	1.26–1.44	1.20E-12

SNPs, Single nucleotide polymorphisms; OR, Odds ratio; CI, Confidence interval; IVW, inverse-variance weighted; IVW (fixed), fixed-effects inverse-variance weighted; MR-RAPS, MR-robust adjusted profile score; MR-PRESSO, MR-pleiotropy residual sum and outlier.

*No outlier was detected.