Table 5.
Pathway analysis on EnrichR of upregulated genes.
| Index | Name | p-value | q-value | OR | Combined score |
|---|---|---|---|---|---|
| Top 10 enriched terms on ENCODE/ChEA consensus database | |||||
| 1 | MYC CHEA | 0,0001482 | 0,01541 | 3,34 | 29,42 |
| 2 | NELFE ENCODE | 0,005354 | 0,1856 | 3,77 | 19,72 |
| 3 | KAT2A ENCODE | 0,02352 | 0,4077 | 4,9 | 18,38 |
| 4 | TRIM28 CHEA | 0,01447 | 0,301 | 3,5 | 14,83 |
| 5 | MYC ENCODE | 0,003164 | 0,1645 | 1,94 | 11,17 |
| 6 | TAF7 ENCODE | 0,01216 | 0,3161 | 2,3 | 10,13 |
| 7 | YY1 CHEA | 0,02612 | 0,3881 | 2,66 | 9,69 |
| 8 | BCL3 ENCODE | 0,03893 | 0,4049 | 2,69 | 8,74 |
| 9 | CEBPD ENCODE | 0,02839 | 0,369 | 2 | 7,14 |
| 10 | ETS1 ENCODE | 0,09047 | 0,5881 | 2,83 | 6,8 |
| Top 10 enriched pathways on Reactome 2016 Human database | |||||
| 1 | Peptide chain elongation R-HSA-156902 | 4,44E-10 | 6,80E-07 | 21,01 | 597,52 |
| 2 | Eukaryotic Translation Elongation R-HSA-156842 | 9,07E-10 | 6,94E-07 | 19,83 | 549,8 |
| 3 | Viral mRNA Translation R-HSA-192823 | 1,16E-08 | 2,96E-06 | 19,26 | 484,89 |
| 4 | Selenocysteine synthesis R-HSA-2408557 | 1,72E-08 | 3,76E-06 | 18,59 | 460,85 |
| 5 | Eukaryotic Translation Termination R-HSA-72764 | 1,72E-08 | 3,29E-06 | 18,59 | 460,85 |
| 6 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975956 | 2,22E-08 | 3,09E-06 | 18,18 | 445,88 |
| 7 | L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156827 | 7,63E-09 | 3,89E-06 | 16,65 | 426,18 |
| 8 | 3’ -UTR-mediated translational regulation R-HSA-157279 | 7,63E-09 | 2,92E-06 | 16,65 | 426,18 |
| 9 | GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72706 | 8,54E-09 | 2,61E-06 | 16,49 | 420,33 |
| 10 | Formation of a pool of free 40S subunits R-HSA-72689 | 5,15E-08 | 6,06E-06 | 16,85 | 399,19 |
(Statistics according to EnrichR).