Table 6.
Pathway analysis on EnrichR of downregulated genes.
| Index | Name | p-value | q-value | OR | Combined score |
|---|---|---|---|---|---|
| Top 10 enriched terms on ENCODE/ChEA consensus database | |||||
| 1 | REST ENCODE | 0,0000579 | 0,006022 | 1,9 | 18,8 |
| 2 | SUZ12 ENCODE | 0,05875 | 1000,0 | 1,8 | 5,0 |
| 3 | AR CHEA | 0,05141 | 1000,0 | 1,2 | 3,6 |
| 4 | REST CHEA | 0,1249 | 1000,0 | 1,1 | 2,4 |
| 5 | SUZ12 CHEA | 0,2426 | 1000,0 | 1,1 | 1,5 |
| 6 | EZH2 CHEA | 0,5243 | 1000,0 | 1,0 | 0,7 |
| 7 | MYOD1 ENCODE | 0,6843 | 1000,0 | 0,9 | 0,3 |
| 8 | POU5F1 CHEA | 0,9057 | 1000,0 | 0,7 | 0,1 |
| 9 | SMAD4 CHEA | 0,9123 | 1000,0 | 0,8 | 0,1 |
| 10 | FOXM1 ENCODE | 0,8949 | 1000,0 | 0,6 | 0,1 |
| Top 10 enriched pathways on Reactome 2016 Human database | |||||
| 1 | Olfactory Signaling Pathway R-HSA-381753 | 5,94E-106 | 9,09E-103 | 7,63 | 1901,15 |
| 2 | GPCR downstream signaling R-HSA-388396 | 1,40E-75 | 1,07E-72 | 4,13 | 739,56 |
| 3 | Signaling by GPCR R-HSA-372790 | 8,37E-60 | 4,27E-57 | 3,29 | 470,72 |
| 4 | Signal Transduction R-HSA-162582 | 3,60E-25 | 1,38E-22 | 1,95 | 123,34 |
| 5 | Recycling of bile acids and salts R-HSA-159418 | 0,000885 | 0,1505 | 6,14 | 43,19 |
| 6 | Multifunctional anion exchangers R-HSA-427601 | 0,004726 | 0,5562 | 7,9 | 42,3 |
| 7 | Xenobiotics R-HSA-211981 | 0,000505 | 0,09653 | 5,53 | 41,98 |
| 8 | Beta defensins R-HSA-1461957 | 0,000154 | 0,0471 | 4,37 | 38,33 |
| 9 | Reduction of cytosolic Ca++ levels R-HSA-418359 | 0,003002 | 0,4175 | 6,14 | 35,69 |
| 10 | Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 | 0,000234 | 0,05118 | 4,15 | 34,67 |
(Statistics according to EnrichR).