Table 1.

Phage display antibody libraries used in the discovery of therapeutic antibodies.

Library name	Company/laboratory	Repertoire	Display format	Size	References
-	Dyax	Naïve	Fab	3.7 × 1010	de Haard et al., 1999
BMV	CAT	Naïve	scFv	1.4 × 1010	Vaughan et al., 1996
CS	CAT	Naïve	scFv	1.29 × 1011	Lloyd et al., 2009
BMV	CAT	Naïve	scFv	1.2 × 1011	Groves et al., 2006
HuCAL	Morphosys’s	Synthetic	Fab	2.1 × 109	Knappik et al., 2000
HuCAL GOLD	Morphosys’s	Synthetic	Fab	1.6 × 1010	Rothe et al., 2008
HuCAL PLATINUM	Morphosys’s	Synthetic	Fab	4.5 × 1010	Prassler et al., 2011
pIX V3.0	Janssen Bio	Synthetic	Fab	3.0 × 1010	Shi et al., 2010
XFab1	Xoma	Naïve	Fab	3.1 × 1011	Schwimmer et al., 2013
XscFv2	Xoma	Naïve	scFv	3.6 × 1011	Schwimmer et al., 2013
PHILODiamond	ETH Zurich	Synthetic	scFv	4.1 × 1010	Weber et al., 2014
ALTHEA Gold Libraries	GlobalBio/ADL	Semi-synthetic	scFv	2.1 × 1010	Valadon et al., 2019
HAL9/10	Technische Universität Braunschweig	Naïve	scFv	1.5 × 1010	Kügler et al., 2015

Library size corresponds to the number of colony forming units (cfu) after the transformation of E. coli with the corresponding DNA library.