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. 2022 Sep 26;9:948488. doi: 10.3389/fnut.2022.948488

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Copyright © 2022 Savino, Durães, Maldonado-Galdeano, Perdigon, Mendes-da-Cruz and Cuervo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative proteomics analysis of thymic interstitial fluid of undernourished-infected mice reveals a non-proliferative quiescent thymic microenvironment. Examples of proteins with differential abundance in the undernourished-infected mice relative to the control (well-nourished) mice are represented in the figure. Proteins involved in transcription and translation as well as proteins involved in cell migration and differentiation were reduced in undernourished mice (red arrows). Conversely, proteins involved in fatty acid beta-oxidation and Krebs’ cycle were increased in those animals (green arrow), compatible with a quiescent, non-proliferative metabolic profile. Such profile was corroborated by a decreased percentage of proliferating thymocyte subsets expressing Ki67. Figure created with BioRender.com, based on data from Losada-Barragán et al. (69).