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. 2022 Sep 26;13:981693. doi: 10.3389/fimmu.2022.981693

Figure 2.

Figure 2

Live virus MNT and SARS-CoV-2 PVNA on sera collected from vaccinated donors produce comparable results. (A, B) 90% live SARS-CoV-2 wild type (WT) neutralization titers (MNT90, left y-axis, hatched bars) and 90% pseudovirus neutralization titers using pseudotyped lentiviruses carrying the WT SΔ19 protein (pVNT90, right y-axis, open bars) in sera drawn from (A) unvaccinated and recipients of two-dose BNT162b2, mRNA-1273, and AZD1222 collected at a median time of ~ 1.5 mo post-second vaccine dose; (B) unvaccinated and recipients of two-dose BNT162b2, mRNA-1273, AZD1222, or one dose Ad26.CO2.S collected at a median time of ~ 4–6 mo post-vaccination. Geometric means ± 95% confidence intervals were reported. Neutralization titers < 10 were considered negative and given an arbitrary value of 5 (dotted line). Kruskal–Wallis test with Dunn’s multiple comparison post-test was used to compare groups. * p < 0.05; ** p ≤ 0.01; *** p ≤ 0.001; **** p < 0.0001. (C) Correlation between pVNT90 and MNT90 titers shown in (A); (D) correlation between pVNT90 and MNT90 titers shown in (B). The non-parametric Spearman’s correlation coefficients (rs), statistically significant p values and ratio between pVNT90 mean titers and MNT90 mean titers were provided. Perfect-fit correlation line was included on the plots. GMT: geometric mean titers; n = number of samples.