Figure 5.

Vaccine booster shots strengthen nAb response against Omicron VOC. (A) Schematic representation of serum collection time points. (B, C) Violin plots representing Log of pVNT₉₀ observed in sera (n = 15) collected at ~ 1 mo or ~ 3 mo after vaccine boost and challenged with (B) SARS-CoV-2 WT or (C) Omicron pseudotyped lentiviruses. A two-tailed non-parametric Mann–Whitney test for unpaired observations was performed. * p < 0.05; ** p ≤ 0.01. (D) pVNT₉₀ titers against Omicron VOC in sera collected at ~ 1 mo and ~ 3 mo after vaccine boost report immune response waning after three months. ** p ≤ 0.01. (E) pVNT90 titers against Omicron VOC observed in sera from three donors infected with SARS-CoV-2 and excluded from the previous analyses. A two-tailed non-parametric Wilcoxon signed-rank test was performed for paired observations (D, E). Geometric mean titers are reported. n = number of samples.