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. 2022 Sep 26;13:1007429. doi: 10.3389/fphar.2022.1007429

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Copyright © 2022 He, Liang, Huang, Jiang, Liu, Sun, Li, Cong and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Somatic mutation analysis and functional enrichment analysis of DEGs in high- and low-risk groups. (A) The waterfall plots showed the somatic mutation landscape in high and low risk groups. (B) Volcano plot presenting the DEGs screened between the high- and low-risk groups. (C) The heat map showing the expression of DEGs in high and low-risk groups. (D) GO analysis of up-regulated and down-regulated genes in high-risk group were performed separately. (E,F) KEGG analysis revealed the main pathways involved in DEGs. (G) Pathway activities in high- and low-risk groups were analyzed using GSVA. DEGs: differentially expressed genes; GO: Gene Ontology; KEGG: Genes and Genomes; GSVA: Gene set variation analysis.