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Sucralose reduces body weight gain and improves physical capacity in mice fed with a high-fat diet. (A) Study design. (B) Body weight. (C) Weight gain. (D) Food intake. (E) Maximal velocity at 4 weeks. (F) Maximal velocity at 8 weeks. Two-way analysis of variance (ANOVA) followed by Holm-Sidak’s post-hoc test. Values are expressed as mean ± SEM. *p < 0.05 vs. CD; #p < 0.05 vs. HFD.
