TABLE 2.

Anti-inflammatory main articles.

BL strain/brand	Model	Relevant information	Year	Reference
Bacillus licheniformis Zhengchangsheng® (BL20386)	Rats	A significant decrease in serum LPS level in the BL & Prebiotic group compared with the high-fat diet group, implying the alleviation of endotoxemia and systemic chronic inflammation. Rat liver was also evaluated for the levels of LPS after treatment. The liver LPS was significantly lower in the BL group compared to the HF group.	2020	Li et al., 2020
MegaSporeBiotic™	Rats	Pretreatment with probiotics BL with other spores resulted in a significant reduction in serum AST, ALT, proinflammatory cytokines (TNF-α, IL-1β), ZO-1 and TAC, as well as hepatocyte necrosis, which was similar to the well-known hepatoprotective agent, silymarin.	2020	Neag et al., 2020
Bacillus licheniformis Zhengchangsheng® (BL20386)	Mice	Studies on the mouse model show that Dextran Sulfate Sodium induced colitis changed the diversity of the intestinal microbial composition and diversity led to an increase of inflammation in colon, which was counteracted by BL administration.	2019	Li et al., 2019
Not specified	Human	The radiotherapy treatment in experiment group markedly upregulated the serum level of ET, CRP, and TNF-α, IL-1β, IL-6.	2018	Du et al., 2018
Not specified	Rats	The treatment of probiotics decreased systematic inflammatory responses as evidenced by the decrease of TNF-α	2017	Deng et al., 2017

Most relevant articles and outcomes of B. licheniformis supplementation in anti-inflammatory effects.