TABLE 3.
Diabetes and obesity main articles.
| BL strain/brand | Model | Relevant information | Year | Reference |
|
Bacillus licheniformis Zhengchangsheng® (BL20386) |
Mice | Decreased weight gain, fat formation, serum lipid profiles, and proinflammatory cytokine values. Improved lipid and glucose metabolism. Nuclear factor-B activation was inhibited, phosphorylated AMP-activated protein kinase activity was enhanced in the liver, and the expression of genes involved in lipid metabolism was modulated. | 2021 | Lu et al., 2021 |
|
Bacillus licheniformis N17-02 |
Vitro | When compared eight different strains of Bacillus, Bacillales and Lactobacillus; though all had different cholesterol-removal abilities, Bacillus licheniformis N17-02 had the best result and presence of bile salt hydrolase gene, as well as most beneficial probiotic characteristics. As a result, it might be a suitable hypocholesterolemic probiotic candidate. | 2021 | He et al., 2021 |
| Not specified | Humans | Twelve-week trial using Bacillus licheniformis in combination with other spore forming bacilli probiotics have remarkable triglyceride lowering. | 2020 | Campbell et al., 2020 |
| Bacillus licheniformis YB9 | Mice | Deoxynivalenol could be degraded by BL (YB9), which also had a high survival rate. Supplementing with Bacillus Licheniformis prevented or reduced the harm. BL could be employed as a potential probiotic supplement for increasing food and feed safety by regulating the intestinal microbiota of both animals and humans, as well as repairing intestinal dysbiosis. | 2020 | Wang et al., 2020 |
|
Bacillus licheniformis Zhengchangsheng® (BL20386) |
Rats | Combining Bacillus licheniformis with Xylooligosaccharides could be a dietary approach to alleviate gut dysbiosis, improve inflammatory status, and thereby reduce disorders linked with high fat diet obesity. | 2020 | Li et al., 2020 |
| Bacillus licheniformis KT921419 | Vitro | For 8 chosen bacterial strains from traditional fermented brine mango pickle, antioxidative, antidiabetic, and antityrosinase properties were investigated. Bacillus licheniformis KT921419 strain showed one of the best results on in vitro experiments and might be used as a new starter or auxiliary culture in a food system to impart health benefits. | 2019 | Ragul et al., 2020 |
| Not specified | Mice | Without affecting food intake, B. licheniformis or a mixture of Bacillus stains reduced final body weight, improved glucose intolerance, and minimized hepatic fat accumulation in mice. Furthermore, the colonic microbiota of the Bacillus-supplemented and high-fat diet-fed mice differed dramatically. Probiotics derived from B. licheniformis could be effective in the management of a variety of metabolic disorders. | 2019 | Cao G. T. et al., 2019 |
| Bacillus licheniformis MCC2512 | Rats | The probiotics B. flexus MCC2427 and B. licheniformis MCC2512 had no negative effects on the health or behavior of the rats. Additional benefits of probiotic cultures include normal hematological parameters, lower blood cholesterol, enhanced HDL-cholesterol, increased cholic acid excretion in the stool, and higher Polyunsaturated fatty acids content in the liver. Bacillus bacteria in the feces was increased, whereas harmful bacteria were decreased. Overall, these probiotic cultures studied are safe and effective, and that they are likely to be safe for human ingestion. | 2018 | Shobharani et al., 2019 |
| Bacillus licheniformis PUFSTP35 | Vitro | When compared eight different strains of Bacillus, the most promising candidate for use as a helpful probiotic appears to be B. licheniformis PUFSTP35 from fermented mango pickle. In vivo investigations to confirm the probiotic potential of the tested isolates are required. | 2017 | Ragul et al., 2017 |
Most relevant articles and outcomes of B. licheniformis supplementation in diabetes and obesity modulation.