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. 2022 Sep 26;9:1010039. doi: 10.3389/fvets.2022.1010039

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Copyright © 2022 Scott, Woolums, Karisch, Harvey and Capik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clustering of enriched KEGG pathways by term identity from KOBAS-i analysis of DEGs identified from glmmSeq evaluation of the interaction between vaccination and time. Each node represents an enriched term, with color corresponding to the unique cluster based on term identity. Each edge (line between nodes) represents a significant correlation between pathway terms. Bar graphs represent the pathway terms found within each pathway (by color) and the level of enrichment (Enrich ratio). KEGG pathways identified through the interaction of vaccination and time clustered into eight unique clusters. Gray nodes and bar graphed terms represent enriched pathways which did not associate within the clustering model.