Table 2.
Univariate and multivariate COX analyses of characteristics extracted from the SEER database.
| Univariate COX analysis | Multivariate COX analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OS | BCSS | OS | BCSS | |||||||||
| HR | 95%CI | P value | HR | 95%CI | P value | HR | 95%CI | P value | HR | 95%CI | P value | |
| Age at diagnosis | ||||||||||||
| < 40 | Reference | Reference | Reference | Reference | ||||||||
| 40–49 | 1.053 | 0.950–1.166 | 0.325 | 1.067 | 0.958–1.189 | 0.236 | 0.999 | 0.879–1.134 | 0.983 | 0.997 | 0.873–1.139 | 0.964 |
| 50–59 | 1.407 | 1.284–1.543 | *** | 1.398 | 1.268–1.541 | *** | 1.198 | 1.067–1.344 | ** | 1.180 | 1.045–1.331 | ** |
| 60–69 | 1.583 | 1.446–1.734 | *** | 1.545 | 1.403–1.701 | *** | 1.370 | 1.218–1.541 | *** | 1.332 | 1.177–1.507 | *** |
| 70–79 | 1.932 | 1.758–2.123 | *** | 1.811 | 1.639–2.003 | *** | 1.517 | 1.334–1.724 | *** | 1.444 | 1.261–1.653 | *** |
| 80+ | 2.908 | 2.637–3.206 | *** | 2.598 | 2.440–2.886 | *** | 2.250 | 1.951–2.596 | *** | 2.028 | 1.741–2.363 | *** |
| Months from diagnosis to therapy | ||||||||||||
| 0 month | Reference | Reference | Reference | Reference | ||||||||
| ≥1 month | 0.850 | 0.813–0.889 | *** | 0.840 | 0.801–0.881 | *** | 0.920 | 0.869–0.974 | ** | 0.909 | 0.856–0.966 | ** |
| Subtype | ||||||||||||
| HR+/HER2– | Reference | Reference | Reference | Reference | ||||||||
| HR+/HER2+ | 0.796 | 0.747–0.848 | *** | 0.809 | 0.756–0.866 | *** | 0.725 | 0.665–0.790 | *** | 0.713 | 0.651–0.781 | *** |
| HR–/HER2+ | 1.082 | 0.991–1.181 | 0.079 | 1.100 | 1.002–1.208 | * | 0.957 | 0.849–1.078 | 0.468 | 0.923 | 0.813–1.048 | 0.216 |
| HR–/HER2- | 2.593 | 2.422–2.776 | *** | 2.761 | 2.567–2.971 | *** | 2.801 | 2.548–3.078 | *** | 2.870 | 2.600–3.169 | *** |
| Race | ||||||||||||
| White | Reference | Reference | Reference | Reference | ||||||||
| Black | 1.310 | 1.239–1.386 | *** | 1.288 | 1.212–1.368 | *** | 1.320 | 1.217–1.431 | *** | 1.290 | 1.183–1.407 | *** |
| Other | 0.923 | 0.859–0.991 | * | 0.921 | 0.853–0.995 | * | 1.013 | 0.916–1.119 | 0.806 | 0.990 | 0.890–1.102 | 0.858 |
| Histological type | ||||||||||||
| IDC | Reference | Reference | Reference | Reference | ||||||||
| ILC | 1.048 | 0.983–1.118 | 0.152 | 1.032 | 0.963–1.106 | 0.367 | 1.249 | 1.135–1.374 | *** | 1.251 | 1.129–1.385 | *** |
| Mixed | 0.894 | 0.818–0.977 | * | 0.901 | 0.821–0.990 | * | 1.055 | 0.946–1.176 | 0.339 | 1.069 | 0.953–1.201 | 0.256 |
| Other | 1.763 | 1.680–1.850 | *** | 1.646 | 1.562–1.735 | *** | 1.267 | 1.134–1.416 | *** | 1.243 | 1.104–1.399 | *** |
| Marriage status | ||||||||||||
| Married | Reference | Reference | Reference | Reference | ||||||||
| Singled | 1.256 | 1.193–1.323 | *** | 1.230 | 1.164–1.300 | *** | 1.173 | 1.089–1.262 | *** | 1.135 | 1.050–1.228 | ** |
| Widow/divorced/other | 1.425 | 1.361–1.491 | *** | 1.366 | 1.301–1.435 | *** | 1.140 | 1.065–1.220 | *** | 1.127 | 1.049–1.212 | ** |
| T Stage | ||||||||||||
| T1 | Reference | Reference | Reference | Reference | ||||||||
| T2 | 1.025 | 0.954–1.102 | 0.496 | 1.041 | 0.963–1.125 | 0.312 | 1.049 | 0.949–1.160 | 0.352 | 1.030 | 0.926–1.147 | 0.583 |
| T3 | 1.145 | 1.057–1.241 | *** | 1.217 | 1.117–1.327 | *** | 1.209 | 1.083–1.350 | *** | 1.221 | 1.086–1.372 | *** |
| T4 | 1.424 | 1.328–1.528 | *** | 1.487 | 1.378–1.604 | *** | 1.244 | 1.124–1.378 | *** | 1.235 | 1.108–1.377 | *** |
| N stage | ||||||||||||
| N0 | Reference | Reference | Reference | Reference | ||||||||
| N1 | 0.907 | 0.861–0.956 | *** | 0.942 | 0.890–0.997 | * | 1.003 | 0.927–1.085 | 0.934 | 1.017 | 0.935–1.106 | 0.697 |
| N2 | 0.850 | 0.787–0.918 | *** | 0.876 | 0.806–0.952 | ** | 1.042 | 0.937–1.159 | 0.445 | 1.063 | 0.949–1.191 | 0.290 |
| N3 | 1.099 | 1.036–1.166 | ** | 1.124 | 1.054–1.198 | *** | 1.142 | 1.041–1.252 | ** | 1.162 | 1.053–1.282 | ** |
| Grade | ||||||||||||
| Well differentiated | Reference | Reference | Reference | Reference | ||||||||
| Moderately differentiated | 1.172 | 1.068–1.287 | *** | 1.189 | 1.076–1.314 | *** | 1.304 | 1.165–1.460 | *** | 1.333 | 1.180–1.506 | *** |
| Poorly differentiated | 1.659 | 1.513–1.820 | *** | 1.720 | 1.557–1.900 | *** | 1.858 | 1.652–2.091 | *** | 1.952 | 1.719–2.217 | *** |
| Median household income(inflation adjusted) | ||||||||||||
| < 50,000$ | Reference | Reference | Reference | Reference | ||||||||
| 50,000–59,999$ | 0.956 | 0.889–1.028 | 0.225 | 0.982 | 0.908–1.062 | 0.648 | 0.998 | 0.903–1.102 | 0.962 | 1.021 | 0.918–1.135 | 0.706 |
| 60,000–69,999$ | 0.914 | 0.857–0.974 | ** | 0.931 | 0.869–0.997 | * | 0.907 | 0.830–0.992 | * | 0.918 | 0.835–1.009 | 0.077 |
| 70,000$ | 0.832 | 0.781–0.886 | *** | 0.835 | 0.780–0.894 | *** | 0.814 | 0.745–0.890 | *** | 0.808 | 0.735–0.889 | *** |
| Neoadjuvant chemotherapy | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.454 | 0.413–0.499 | *** | 0.472 | 0.427–0.522 | *** | 0.802 | 0.714–0.900 | *** | 0.805 | 0.712–0.909 | *** |
| Chemotherapy | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.550 | 0.529–0.572 | *** | 0.585 | 0.561–0.611 | *** | 0.672 | 0.629–0.718 | *** | 0.685 | 0.639–0.735 | *** |
| Radiotherapy | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.783 | 0.751–0.817 | *** | 0.801 | 0.766–0.839 | *** | 1.098 | 1.035–1.165 | ** | 1.101 | 1.034–1.173 | ** |
| Surgery | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.505 | 0.479–0.533 | *** | 0.514 | 0.486–0.544 | *** | 0.648 | 0.604–0.696 | *** | 0.647 | 0.600–0.697 | *** |
| Liver metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.812 | 1.734–1.894 | *** | 1.882 | 1.796–1.973 | *** | 1.752 | 1.637–1.875 | *** | 1.825 | 1.698–1.960 | *** |
| Lung metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.593 | 1.525–1.663 | *** | 1.596 | 1.523–1.671 | *** | 1.298 | 1.216–1.385 | *** | 1.282 | 1.196–1.373 | *** |
| Brain metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.976 | 1.843–2.119 | *** | 2.056 | 1.910–2.214 | *** | 1.829 | 1.649–2.030 | *** | 1.850 | 1.658–2.064 | *** |
| Distant Lymph nodes metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.246 | 1.155–1.345 | *** | 1.244 | 1.146–1.350 | *** | 1.002 | 0.888–1.130 | 0.980 | 1.004 | 0.883–1.140 | 0.955 |
| Distant other metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.580 | 1.450–1.722 | *** | 1.567 | 1.428–1.719 | *** | 1.296 | 1.112–1.510 | *** | 1.291 | 1.098–1.518 | ** |
*P < 0.05, **P < 0.01, ***P < 0.001.