Table 1.
Descriptive information of Caucasian and Han Chinese cohorts at baseline.
| Caucasian samples (n = 1738) |
Missing data (%) |
Han Chinese samples (n = 296) |
Missing data (%) |
p | |
|---|---|---|---|---|---|
| Demographic characteristics | |||||
| Age, [mean (SD)] | 68.37 (12.62) | 0 (0) | 69.39 (13.37) | 0 (0) | 0.2 |
| Male, n (%) | 1016 (58.5) | 0 (0) | 165 (55.7) | 0 (0) | 0.408 |
| Medical history | |||||
| Myocardial infarction, n (%) | 255 (14.7) | 0 (0) | 4 (1.4) | 0 (0) | <0.001 |
| Atrial fibrillation, n (%) | 426 (24.5) | 0 (0) | 81 (27.4) | 0 (0) | 0.309 |
| Hypertension, n (%) | 1218 (70.1) | 0 (0) | 175 (59.1) | 0 (0) | <0.001 |
| Diabetes mellitus, n (%) | 316 (18.2) | 0 (0) | 70 (23.6) | 0 (0) | 0.03 |
| Previous stroke, n (%) | 238 (13.7) | 0 (0) | 36 (12.2) | 0 (0) | 0.52 |
| Previous TIA, n (%) | 142 (8.6) | 89 (5.1) | 2 (0.7) | 0 (0) | <0.001 |
| Smoker, n (%) | 852 (49.1) | 4 (0.2) | 109 (36.8) | 0 (0) | <0.001 |
| Previous medication | |||||
| Previous anticoagulation, n (%) | 81 (4.7) | 0 (0) | 17 (5.7) | 0 (0) | 0.462 |
| Previous antiplatelet, n (%) | 647 (37.2) | 0 (0) | 29 (9.8) | 0 (0) | < 0.001 |
| Clinical characteristics | |||||
| Onset to treatment time, (median [IQR]) | 3.42 [2.92, 3.88] | 0 (0) | 3.00 [2.00, 4.00] | 0 (0) | < 0.001 |
| NIHSS score on admission, (median [IQR]) | 14.00 [10.00, 18.00] | 0 (0) | 9.00 [4.75, 15.00] | 0 (0) | < 0.001 |
| Systolic blood pressure on admission, [mean (SD)] | 152.82 (24.47) | 0 (0) | 148.96 (24.95) | 0 (0) | 0.013 |
| Diastolic blood pressure on admission, [mean (SD)] | 81.32 (16.31) | 22 (1.3) | 84.35 (15.76) | 0 (0) | 0.003 |
| Cardioembolic stroke, n(%) | 820 (47.5) | 13 (0.7) | 82 (27.7) | 0 (0) | < 0.001 |
| Baseline blood biomarkers | |||||
| Blood glucose, [mean (SD)] | 7.38 (2.82) | 253 (14.6) | 8.10 (2.96) | 0 (0) | < 0.001 |
| Neutrophils, [mean (SD)] | 7.43 (3.12) | 489 (28.1) | 6.25 (3.09) | 0 (0) | < 0.001 |
| Platelet count, [mean (SD)] | 234.88 (74.92) | 372 (21.4) | 184.04 (60.34) | 0 (0) | < 0.001 |
| Total bilirubin, [mean (SD)] | 7.87 (4.58) | 171 (9.8) | 11.52 (6.38) | 0 (0) | < 0.001 |
| Creatinine, [mean (SD)] | 83.91 (23.89) | 86 (4.9) | 84.15 (57.13) | 0 (0) | 0.906 |
| Alkaline phosphatase, [mean (SD)] | 78.76 (35.92) | 129 (7.4) | 81.48 (24.97) | 0 (0) | 0.212 |
| Alanine aminotransferase, [mean (SD)] | 24.07 (23.69) | 258 (14.8) | 23.05 (17.20) | 0 (0) | 0.482 |
| Aspartate aminotransferase, [mean (SD)] | 25.13 (20.75) | 375 (21.6) | 25.02 (12.69) | 0 (0) | 0.928 |
| Neuroimaging markers on initial CT scan | |||||
| ASPECT Score, (median [IQR]) | 10.00 [10.00, 10.00] | 20 (1.2) | 9.00 [8.00, 10.00] | 0 (0) | < 0.001 |
| Hypodensity, n (%) | 131 (7.6) | 20 (1.2) | 178 (60.1) | 0 (0) | < 0.001 |
| >1/3 MCA territory, n (%) | 3 (0.2) | 20 (1.2) | 71 (24.0) | 0 (0) | < 0.001 |
| Midline shift, n (%) | 1 (0.1) | 20 (1.2) | 3 (1.0) | 0 (0) | 0.011 |
| sICH, n (%) | 85 (4.9) | 0 (0) | 29 (9.8) | 0 (0) | 0.001 |
ASPECT Score, Alberta Stroke Program Early CT score; MCA, middle cerebral artery; sICH, symptomatic intracerebral hemorrhage; TIA, transient ischemic attack.