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. 2022 Sep 26;15:1019446. doi: 10.3389/fnmol.2022.1019446

FIGURE 1.

FIGURE 1

Chronic HFD leads to weight gain, overeating, physical inactivity, and metabolic disorders. (A) Photo of representative ND and HFD mice. (B) Average body weight of ND and HFD mice (n = 7–8, two-tailed unpaired t-test). (C) Food ingested during the day (left), night (middle), and 24 h (right) for ND and HFD mice (n = 6–9, two-way ANOVA, Bonferroni post hoc analysis). (D) Representative track plots of open field activity for ND and HFD mice. (E,F) The total traveled distance (E) and movement speed (F) of ND and HFD mice. (G) Blood glucose levels during the glucose tolerance test (left, GTT) and area under the curve (right, AUC) in ND and HFD mice (n = 3–6, two-tailed unpaired t-test). (H) Blood glucose levels during the insulin tolerance test (left, ITT) and area under the curve (right, AUC) in ND and HFD mice (n = 3–4, two-tailed unpaired t-test). Data are means ± SEMs. Dots represent individual experimental animals. *p < 0.05; **p < 0.01; ***p < 0.001 as indicated.