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. 2022 Sep 26;15:1019446. doi: 10.3389/fnmol.2022.1019446

FIGURE 5.

FIGURE 5

Chronic HFD consumption impairs synaptic transmission in the NAc. (A) Representative mEPSC traces recorded from NAc neurons for ND and HFD mice. (B,C) Cumulative fraction curves of inter-event intervals (B) and mean frequency (C) of mEPSCs (n = 3 mice, 18–20 cells, Mann-Whitney test). (D,E) Cumulative fraction curves of amplitudes (D) and mean amplitude (E) of mEPSCs (n = 3 mice, 18–20 cells, two-tailed unpaired t-test). (F) Representative mIPSC traces recorded from NAc neurons for ND and HFD mice. (G,H) Cumulative fraction curves of inter-event intervals (G) and mean frequency (H) of mIPSCs (n = 3 mice, 17–19 cells, Mann-Whitney test). (I,J) Cumulative fraction curves of amplitudes (I) and mean amplitude (J) of mIPSCs (n = 3 mice, 17–19 cells, two-tailed unpaired t-test). (K) Ratio between mEPSC and mIPSC amplitudes in the same neurons from different brain regions in ND and HFD mice (n = 3–4 mice, 9–19 cells, Mann-Whitney test). Data are means ± SEMs. Dots represent individual experimental cells. *p < 0.05; **p < 0.01 as indicated.