Figure 2.

Lactic acid levels in the peripheral circulation are modulated early during treatment with Bev/Evo to an extent that is associated with tumor hypoxia levels prior to treatment. Changes in the levels of the blood metabolite after treatment (i.e. levels at cycle 2 normalized to the matched levels prior to treatment) significantly correlate with HV. The Pearson correlation linear regression is shown with the black dashed line. Datapoints for each patient are shown in orange for patients enrolled at the University of Texas Health Science Center in San Antonio (UTHSCSA; 3 patient samples) and in blue for patients enrolled at Dana-Farber Cancer Institute (CI; 7 patient samples). Evaluation of significance included corrections for repeated measurements and sample permutation (100,000 permutations) statistical tests (included in Supplementary Figure 1 ).