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. 2022 Sep 26;13:988130. doi: 10.3389/fimmu.2022.988130

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Copyright © 2022 Liu, Zheng and Liao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of m6A RNA modifications in early embryo development and placentation. The downregulation of the m6A RNA modifications METTL3, METTL14, METTL16, MAT2A, VIRMA, WATP, YTHDF2, hnRNPA2/B1 and IGF2BP2/3 is related to early embryo development; however, the upregulation of IGF2BP3 also causes a delay in late development. In addition, the decrease in FTO and YTHDF2 is associated with early placental dysfunction, while the overexpression of METTL3/ALKBH5 is related to late abnormal placentation.