Table 2.

MultivariateCoxregressionanalysis of prognostic factors on PFS of all enrolled patients

Variable	n	P	HR	95%CI
CNS: central nervous system.
Gender		0.002	0.358	0.185-0.693
Female	67
Male	40
Age (yr)		0.201	0.585	0.275-1.330
> 65	30
≤65	77
ECOG PS		0.133	0.558	0.260-1.193
0	24
1-2	83
Clinical stage		0.003	0.404	0.221-0.737
IVA	22
IVB	85
CNS metastasis		0.330	0.717	0.367-1.400
Yes	39
No	68
EGFR mutation		0.297	1.393	0.747-2.596
Exon 19 deletion	50
Other	57
Concomitant non-EGFR mutation		0.611	0.841	0.431-1.640
TP53	53
Other	54
Number of concomitant non-EGFR mutations		0.152	0.478	0.174-1.313
1	83
≥2	24
Treatment protocol		< 0.001	0.132	0.062-0.281
Combination therapy	63
TKIs monotherapy	44
Type of EGFR-TKIs		0.182	0.275	0.041-1.831
First-generation	102
Other	5