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. 2022 Oct 10;28:122. doi: 10.1186/s10020-022-00548-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Box plots and receiver operating characteristic (ROC) curves for leading biomarkers, ANG-1 and P-SEL. A A boxplot demonstrating significantly elevated blood ANG-1 concentrations in Long-COVID outpatients (****P < 0.0001). B ROC curves demonstrating the excellent Long-COVID classification potential of blood ANG-1 versus healthy control subjects (AUC = 1.00, P < 0.0001) and acutely ill COVID-19 inpatients (AUC = 1.00, P < 0.0001). ROC curve for Long-COVID versus healthy control (green) hidden by ROC curve for Long-COVID versus acutely ill COVID-19 patients. C A boxplot demonstrating significantly elevated blood P-SEL concentrations in Long-COVID outpatients (****P < 0.0001; ***P < 0.001). D ROC curves demonstrating the excellent Long-COVID classification potential of blood P-SEL versus healthy control subjects (AUC = 1.00, P < 0.0001) and acutely ill COVID-19 inpatients (AUC = 1.00, P < 0.0001). ROC curve for Long-COVID versus healthy control (green) hidden by ROC curve for Long-COVID versus acutely ill COVID-19 patients