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. 2022 Oct 10;8:38. doi: 10.1038/s41540-022-00250-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Adjusted enrichment E_adj values obtained in each of the 16 significantly actionable MIS interventions (empirical null distribution p(A(s)) < 0.05) computed for the drug pairs with the top ten highest overall weighted median adjusted enrichment (WM E_adj). Drug pairs are ordered along the vertical axis by increasing weighted median E_adj and MIS solutions along the horizontal axis by increasing residual Manhattan distance (bits) separating the treatment outcome from the target healthy resting state. Asterisks indicate an E_adj value with an empirical null distribution p(E_adj) < 0.05 significance.