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. 2022 Oct 10;8:38. doi: 10.1038/s41540-022-00250-9

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Maximum adjusted enrichment (max E_adj) obtained for any single idealized intervention (MIS) versus the aggregate performance expressed as the weighted median adjusted enrichment (WM E_adj) across all 16 significantly actionable MIS solutions for the top ten ranked single drugs (blue dots) and drug pairs (orange dots) (Additional File 1, Supplementary Tables 2 and 3).