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. 2022 Oct 10;8:38. doi: 10.1038/s41540-022-00250-9

Fig. 6. Simulating synergistic companions to dexamethasone.

Fig. 6

Discrete event simulation using synchronous state transition update of host immune network showing the overall Manhattan distance from the target immune resting state as a function of iteration. An idealized antiviral is applied to an initial persistent state approximating cytokine storm along with a dexamethasone alone, acetylcholine alone and a combination of both, b dexamethasone alone, medroxyprogesterone acetate alone and a combination of both, and c dexamethasone alone, ciprofloxacin alone and a combination of both, and d dexamethasone alone, rapamycin alone and a combination of both. In all cases, we see a positive synergy indicative of complementary drug actions.