Table 3. Immune cells in ectocervical tissue at the end of treatment (visit 31) based on treatment and dosing assignment.

	TFVLNG continuous				TFVLNG Interrupted				Placebo Continuous				Placebo Interrupted				P
	N	Median	IQR 25	IQR 75	N	Median	IQR 25	IQR 75	N	Median	IQR 25	IQR 75	N	Median	IQR 25	IQR 75
Histology
Epithelial Thickness (μm)	13	240	206.7	268	15	298	223.3	378.3	5	236.7	180	306.7	4	258.5	191.8	372.5	0.32
Number Cell Layers	13	17.4	16.3	19.5	15	21.7	19.7	23.3	5	16.2	13.3	20.5	4	17.3	14.1	24.2	0.23
Cells in the Ectocervical Epithelium (cells/mm2)
CD45	13	107.9	90.2	119.7	15	67.3	54.3	115.3	5	116.2	67.6	148.5	4	101.9	65.1	143.3	0.36
CD3	13	67.9	57.3	80.2	15	47.9	33.3	77.3	5	80.8	47.4	122.9	4	69.9	49.3	90.5	0.32
CD8	13	43.6	36.7	61.7	15	30.4	10.7	58.5	5	47.1	32	84.5	4	40.6	27.2	59	0.27
HLADR	13	36.7	30.3	46.2	15	36.5	30.8	50.2	5	65.7	20.5	78.7	4	30.7	25.7	50.3	0.82
Cells in the Ectocervical Lamina Propria (cells/mm2)
CD45	13	72	64	148	13	86.4	52	144	5	93.3	72	112	4	94	70	169.6	0.96
CD3	13	38.4	36	106.7	13	48	32	82.7	5	56	38.4	80	4	49.3	36	108.5	0.97
CD8	13	22.4	16	52	13	24	12	48	5	26.7	22.4	44.8	4	28	20	60.8	0.92
HLADR	13	42.7	28	48	13	48	40	64	5	44.8	32	50.7	4	43.3	32	44.7	0.62

IQR = Interquartile range

* p values determined using Kruskall Wallis test.