TABLE 3.

Hazard ratio for death and cardiovascular events based on the Cr/CysC ratio in 1,966 adults with chronic kidney disease.

	Crude		Model 1		Model 2
	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
Composite outcomes
Continuous (per 1 unit Cr/CysC)	0.93 (0.87–0.99)	0.02	0.87 (0.80–0.95)	0.01	0.92 (0.85–0.99)	0.05
Categorical
Q1	1.00 (reference)		1.00 (reference)		1.00 (reference)
Q2	0.67 (0.48–0.92)	0.01	0.75 (0.53–1.01)	0.08	0.82 (0.59–1.14)	0.2
Q3	0.53 (0.38–0.74)	<0.001	0.62 (0.44–0.87)	0.01	0.71 (0.50–1.01)	0.06
Q4	0.39 (0.27–0.53)	<0.001	0.55 (0.37–0.82)	0.01	0.69 (0.45–0.99)	0.05
All-cause death
Continuous (per 1 unit Cr/CysC)	0.94 (0.86–1.02)	0.1	0.83 (0.74–0.93)	0.01	0.87 (0.78–0.97)	0.02
Categorical
Q1	1.00 (reference)		1.00 (reference)		1.00 (reference)
Q2	0.68 (0.42–1.02)	0.06	0.66 (0.42–1.04)	0.08	0.78 (0.49–1.23)	0.3
Q3	0.58 (0.37–0.91)	0.02	0.57 (0.35–0.91)	0.02	0.68 (0.42–1.10)	0.1
Q4	0.39 (0.23–0.66)	<0.001	0.42 (0.24–0.74)	0.01	0.54 (0.30–0.97)	0.04
Cardiovascular events
Continuous (per 1 unit Cr/CysC)	0.92 (0.85–1.00)	0.05	0.89 (0.80–0.99)	0.04	0.93 (0.84–1.04)	0.2
Categorical
Q1	1.00 (reference)		1.00 (reference)		1.00 (reference)
Q2	0.67 (0.45–0.99)	0.05	0.79 (0.52–1.19)	0.3	0.80 (0.53–1.21)	0.3
Q3	0.53 (0.35–0.81)	0.01	0.67 (0.43–1.03)	0.07	0.72 (0.46–1.12)	0.1
Q4	0.38 (0.24–0.61)	<0.001	0.60 (0.36–1.00)	0.05	0.72 (0.43–1.21)	0.2

Model 1, adjusted for age, sex, estimated glomerular filtration rate, and natural log of albuminuria. Model 2, additionally adjusted for diabetes, cardiovascular disease, body mass index, systolic blood pressure, current smoking, albumin, and the natural log of C-reactive protein. CI, confidence interval.