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. 2022 Sep 20;9:rbac069. doi: 10.1093/rb/rbac069

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — GOx-incorporated hydrogels releasing H₂O₂ in the presence of glucose: (A) antibacterial peptide-based prepared via self-assembly of IKYLSVN hetapeptide to reduce bacterial infection: (i) concentration of H₂O₂ released at different time, and (ii) excellent antibacterial effect against E. coli. Reprinted and modified with permission from Ref. [122] Copyright 2020 American Scientific Publishers. Gelatin-based hydrogel prepared by HRP-catalyzed crosslinking reaction to (B) accelerate the neovascularization: (i) cumulative release of H₂O₂ within 48 h, and (ii) neovascularization property through chorioallantoic membrane assay. Reprinted and modified with permission from Ref. [124] Copyright 2018 American Chemical Society, and to (C) promote bone regeneration by co-delivery of cell surface-specific GRP78 and tonsil-derived MSCs: (i) sustained release of H₂O₂ for upto 30 days, and improvement in (ii) bone volume and (iii) bone mineral density after implantation. Reprinted and modified with permission from Ref. [125] Copyright 2021 Elsevier Ltd.