Table 4.

Univariate and multivariate analyses of prognostic factors for overall survival (OS) after radical gastrectomy of stage II/III gastric cancer (n = 2352).

Variables	N	Median OS (Months)	UV P value	MV HR (95% CI)	MV P value
Gender
Male	1563	56	0.975
Female	789	57
Age (years)
≥ 65	547	40	<0.001		0.385
< 65	1805	62
Body Mass Index (kg/m2)
≥ 25	338	89	0.021		0.100
< 25	2014	53
ASA score
≥ 3	241	36	<0.001	1.248 (1.033–1.508)	0.022
< 3	2111	62
Comorbidities
Yes	705	63	0.472
No	1647	55
Hemoglobin (g/L)
≥ 100	1783	60	0.179
< 100	569	48
Prognostic nutritional index			<0.001
< 43.9	633	38		1.163 (1.007–1.343)	0.039
≥ 43.9	1719	63
TNM stage*
III	1733	36	<0.001	3.016 (2.509–3.627)	<0.001
II	619	NA†
Peri-operative blood transfusion
Yes	543	34	<0.001	1.170 (1.006–1.361)	0.042
No	1809	63
Post-operative infectious complication
Yes	160	29	<0.001	1.347 (1.067–1.700)	0.012
No	2192	60
Adjuvant chemotherapy
No	653	34	<0.001	1.610 (1.197–1.855)	<0.001
Yes	1699	68

ASA American Society of Anesthesiologist; OS Overall survival; CI Confidence interval; HR Hazard ratio; UV Univariate analysis; MV Multivariate analysis.

*Tumor stages are based on 8th edition of AJCC TNM classification.

^†The median overall survival time has not reached during the follow-up.