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. 2022 Sep 29;19(10):1221–1229. doi: 10.1038/s41592-022-01606-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Overview of all single-cell clusters (except Negative). Notably, the patterns organize into cytosolic (bottom-left) and nuclear (top-right) meta-clusters. b, Cells with both the Cytosol and the Nucleoplasm labels lie between the two respective clusters. The majority of negative cells cluster into a separate corner with a slight overlap with Cytosol and Nucleoplasm clusters. c, Cells labeled with Vesicles and punctate pattern (Ves. Punct.) in the cytosol, endoplasmic reticulum (ER) and the Golgi apparatus cluster together at the opposite end to the nuclear patterns in the three-dimensional UMAP plot. Cells labeled Vesicles can be found in these other clusters, capturing the cellular dynamics of the class. Actin fil., Actin filaments; Golgi, Golgi apparatus; Int. Fil, Intermediate filaments; M. Spindle, Mitotic spindle; Nuc. Bodies, Nuclear bodies; Nuc. Fib. C., Nucleolar fibrillar center; Nuc. Membrane, Nuclear membrane; Nuc. Speckle, Nuclear speckle; Pl. Membrane, Plasma membrane.