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Proposed central nervous system (CNS) effects of Bruton's tyrosine kinase (BTK) inhibitors. The inhibition of BTK is thought to (a) block the activation of microglial cells, (b) promote the remyelination of axons by affecting oligodendrocytes and their precursors, and (c) prevent the extravasation of peripheral immune cells into the CNS. Green arrows indicate a promoting effect of BTK inhibitors whereas red symbols correspond to inhibitory effects
