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. 2022 Aug 30;40(11):1107–1117. doi: 10.1007/s40273-022-01181-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Number of patients diagnosed with cancer (overall total and example cancers). Note: The total number of cancers diagnosed by multi-cancer early detection (MCED) plus usual care are higher than those diagnosed by the usual care arm alone as the base case considers overdiagnosis. Overall stage shift represents a combination of cancers that have a substantial stage shift due to MCED (e.g., esophageal) and those with a more modest stage shift (e.g., hormone receptor positive [HR+] breast cancer)