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. 2022 Oct 10;13:5959. doi: 10.1038/s41467-022-33555-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Kaplan–Meier plot for TMB in the overall cohort and b treatment arm effect of TMB and DFS association stratified by median cutoff. Data are presented as HR and 95% CI. ¹Cox proportional hazards model with <Median as the reference group was used to calculate HR and 95% CI. ²Log-rank two-sided test was performed to compare between overall median cutoff groups. A HR <1 indicates better survival in the ≥Median group, while a HR >1 indicates better survival in the <Median group. HR reference level is <median, p-value is from Logrank test. ³Two-sided p-value for overall median cutoff-by-treatment interaction from Cox model with treatment group and median cutoff status as two independent variables. CI confidence interval, DFS disease-free survival, HR hazard ratio, NE not estimable, TMB tumor mutational burden.