Fig. 3. DFS according to previously defined gene expression signatures.

a Kaplan–Meier plot in the overall population for the IMmotion 150 myeloid inflammation signature; b Forest plot with treatment arm effect for the association of RNA sequence expression and DFS stratified by median cutoff; data are presented as HR and 95% CI; Kaplan–Meier plot in the overall population of c IMmotion 150 Teff signature; d JAVELIN Renal 101-Immune signature; e IMmotion 150-Angio Signature; and f JAVELIN Renal 101-Angio signature. HR <1 indicates longer DFS in the ≥Median group; HR >1 indicates longer DFS in the <Median group. ¹Cox proportional hazards model with <median as the reference group was used to calculate HR and 95% CI. ²Cox regression HR p-value is used to compare between overall median cutoff groups. A HR <1 indicates better survival in the ≧Median group, while a HR >1 indicates better survival in the <Median group. HR reference level is <median, p-value is from Logrank test. ³Two-sided p-value for overall median cutoff-by-treatment interaction from Cox model with treatment group and median cutoff status as two independent variables. HR analyses are adjusted for sex and age (<65, ≥65), using proportional hazards modeling. No adjustments were made for multiple comparisons. Angio angiogenesis, CI confidence interval, DFS disease-free survival, HR hazard ratio, NE not estimable, Teff effector T cell.