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. 2022 Oct 10;13:5959. doi: 10.1038/s41467-022-33555-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Discovery of the STRAC11 GES [derived from the sunitinib-treated S-TRAC trial population] according to bootstrapping frequency. Kaplan–Meier plot of b differential DFS probability by STRAC11 in the S-TRAC placebo arm and c sunitinib arm. Kaplan–Meier plot of differential d PFS probability and e OS probability by STRAC11 in the TCGA data set; f differential PFS by STRAC11 in the JAVELIN Renal 101 overall population data set and g by treatment arm. AMT aminomethyltransferase, APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A, ARRDC1 arrestin domain-containing 1, CI confidence interval, DFS disease-free survival, HR hazard ratio, MERTK MER tyrosine kinase, MROH8 maestro heat like repeat family member 8, NE not estimable, PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1, SLC16A1 solute carrier family 16, member 1, SLPI secretory leukocyte peptidase inhibitor, SNX29 sorting nexin 29, STEAP1 six transmembrane epithelial antigen of the prostate family member 1, TCGA The Cancer Genome Atlas, TDO2 tryptophan 2,3-dioxygenase.